| Pair Name | Rutin, Oxaliplatin | ||
| Phytochemical Name | Rutin (PubChem CID: 5280805 ) | ||
| Anticancer drug Name | Oxaliplatin (PubChem CID: 9887053 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Drug Name | Oxaliplatin |
| Adverse Reactions | Nausea, vomiting, diarrhoea, loss of appetite. This was inferred cold nature anticancer drug. |
| Recommendations | Hot: Datura metel; Citrus reticulata |
| Reference | Traditional Chinese medicine characteristics of chemotherapy regimens in advanced gastrointestinal malignant tumours[J]. Global Traditional Chinese Medicine,2023,16(8):1596-1599. DOI:10.3969/j.issn.1674-1749.2023.08.019. ref_link |
| Pair Name | Rutin, Oxaliplatin | |||
| Disease Info | [ICD-11: 2B72] | Gastric cancer | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G0/G1 phase | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Cleavage | CASP7 | hsa840 | |
| Up-regulation | Cleavage | CASP8 | hsa841 | |
| Up-regulation | Cleavage | CASP9 | hsa842 | |
| Up-regulation | Phosphorylation | MAPK14 | hsa1432 | |
| In Vitro Model | SGC-7901 | Human papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_0520 |
| Result | P38 Signal Transduction Pathway Has More Cofactors on Apoptosis of SGC-7901 Gastric Cancer Cells Induced by Combination of Rutin and Oxaliplatin | |||
| No. | Title | Href |
|---|---|---|
| 1 | P38 Signal Transduction Pathway Has More Cofactors on Apoptosis of SGC-7901 Gastric Cancer Cells Induced by Combination of Rutin and Oxaliplatin. Biomed Res Int. 2019 Nov 6;2019:6407210. doi: 10.1155/2019/6407210. | Click |
